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dc.contributor.authorSparrow, Daviden_US
dc.contributor.authorDeAngelis, Tamara R.en_US
dc.contributor.authorHendron, Kathrynen_US
dc.contributor.authorThomas, Cathi A.en_US
dc.contributor.authorSaint-Hilaire, Marieen_US
dc.contributor.authorEllis, Terryen_US
dc.date.accessioned2018-08-22T12:51:48Z
dc.date.available2018-08-22T12:51:48Z
dc.date.issued2016-01-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000375229200005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationDavid Sparrow, Tamara R DeAngelis, Kathryn Hendron, Cathi A Thomas, Marie Saint-Hilaire, Terry Ellis. 2016. "Highly Challenging Balance Program Reduces Fall Rate in Parkinson Disease." JOURNAL OF NEUROLOGIC PHYSICAL THERAPY, Volume 40, Issue 1, pp. 24 - 30 (7). https://doi.org/10.1097/NPT.0000000000000111
dc.identifier.issn1557-0576
dc.identifier.issn1557-0584
dc.identifier.urihttps://hdl.handle.net/2144/30877
dc.descriptionPublished in final edited form as: J Neurol Phys Ther. 2016 January ; 40(1): 24–30. doi:10.1097/NPT.0000000000000111en_US
dc.description.abstractBACKGROUND AND PURPOSE: There is a paucity of effective treatment options to reduce falls in Parkinson disease (PD). Although a variety of rehabilitative approaches have been shown to improve balance, evidence of a reduction in falls has been mixed. Prior balance trials suggest that programs with highly challenging exercises had superior outcomes. We investigated the effects of a theory-driven, progressive, highly challenging group exercise program on fall rate, balance, and fear of falling. METHODS: Twenty-three subjects with PD participated in this randomized cross-over trial. Subjects were randomly allocated to 3 months of active balance exercises or usual care followed by the reverse. During the active condition, subjects participated in a progressive, highly challenging group exercise program twice weekly for 90 minutes. Outcomes included a change in fall rate over the 3-month active period and differences in balance (Mini-Balance Evaluation Systems Test [Mini-BESTest]), and fear of falling (Falls Efficacy Scale-International [FES-I]) between active and usual care conditions. RESULTS: The effect of time on falls was significant (regression coefficient = -0.015 per day, P < 0.001). The estimated rate ratio comparing incidence rates at time points 1 month apart was 0.632 (95% confidence interval, 0.524-0.763). Thus, there was an estimated 37% decline in fall rate per month (95% confidence interval, 24%-48%). Improvements were also observed on the Mini-BESTest (P = 0.037) and FES-I (P = 0.059). DISCUSSION AND CONCLUSIONS: The results of this study show that a theory-based, highly challenging, and progressive exercise program was effective in reducing falls, improving balance, and reducing fear of falling in PD.Video abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A120). TRIAL REGISTRATION: ClinicalTrials.gov NCT02302144.en_US
dc.description.sponsorshipThis study was funded by the Boston Claude D. Pepper Older Americans Independence Center (NIH 5P30AG031679). Additional support was provided by the American Parkinson Disease Association (ADPA); ADPAMA Chapter. (NIH 5P30AG031679 - Boston Claude D. Pepper Older Americans Independence Center; American Parkinson Disease Association (ADPA); ADPAMA Chapter)en_US
dc.format.extentp. 24 - 30en_US
dc.languageEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJournal of Neurologic Physical Therapy
dc.relation.isversionofhttps://doi.org/10.1097/NPT.0000000000000111
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectClinical neurologyen_US
dc.subjectRehabilitationen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectBalanceen_US
dc.subjectExerciseen_US
dc.subjectFallsen_US
dc.subjectParkinson diseaseen_US
dc.subjectPostural controlen_US
dc.subjectRandomized controlled trialen_US
dc.subjectPostural responsesen_US
dc.subjectPrevention trialsen_US
dc.subjectAccidental fallsen_US
dc.subjectAgeden_US
dc.subjectCross-over studiesen_US
dc.subjectExercise therapyen_US
dc.subjectFearen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectOutcome assessment (health care)en_US
dc.subjectPostural balanceen_US
dc.subjectTreatment outcomeen_US
dc.titleHighly challenging balance program reduces fall rate in Parkinson diseaseen_US
dc.typeArticleen_US
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.organisational-groupBoston University, School of Medicineen_US
pubs.publication-statusPublisheden_US


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