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dc.contributor.authorPaul, Serene S.en_US
dc.contributor.authorThackeray, Anneen_US
dc.contributor.authorDuncan, Ryan P.en_US
dc.contributor.authorCavanaugh, James T.en_US
dc.contributor.authorEllis, Theresa D.en_US
dc.contributor.authorEarhart, Gammon M.en_US
dc.contributor.authorFord, Matthew P.en_US
dc.contributor.authorForeman, K. Boen_US
dc.contributor.authorDibble, Leland E.en_US
dc.date.accessioned2018-08-22T15:28:06Z
dc.date.available2018-08-22T15:28:06Z
dc.date.issued2016-03-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371850100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationSerene S Paul, Anne Thackeray, Ryan P Duncan, James T Cavanaugh, Theresa D Ellis, Gammon M Earhart, Matthew P Ford, K Bo Foreman, Leland E Dibble. 2016. "Two-Year Trajectory of Fall Risk in People With Parkinson Disease: A Latent Class Analysis." Archives Of Physical Medicine And Rehabilitation, Volume 97, Issue 3, pp. 372 - 379 (8). https://doi.org/10.1016/j.apmr.2015.10.105
dc.identifier.issn0003-9993
dc.identifier.issn1532-821X
dc.identifier.urihttps://hdl.handle.net/2144/30890
dc.descriptionPublished in final edited form as: Arch Phys Med Rehabil. 2016 March ; 97(3): 372–379.e1. doi:10.1016/j.apmr.2015.10.105.en_US
dc.description.abstractOBJECTIVE: To examine fall risk trajectories occurring naturally in a sample of individuals with early to middle stage Parkinson disease (PD). DESIGN: Latent class analysis, specifically growth mixture modeling (GMM), of longitudinal fall risk trajectories. SETTING: Assessments were conducted at 1 of 4 universities. PARTICIPANTS: Community-dwelling participants with PD of a longitudinal cohort study who attended at least 2 of 5 assessments over a 2-year follow-up period (N=230). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Fall risk trajectory (low, medium, or high risk) and stability of fall risk trajectory (stable or fluctuating). Fall risk was determined at 6 monthly intervals using a simple clinical tool based on fall history, freezing of gait, and gait speed. RESULTS: The GMM optimally grouped participants into 3 fall risk trajectories that closely mirrored baseline fall risk status (P=.001). The high fall risk trajectory was most common (42.6%) and included participants with longer and more severe disease and with higher postural instability and gait disability (PIGD) scores than the low and medium fall risk trajectories (P<.001). Fluctuating fall risk (posterior probability <0.8 of belonging to any trajectory) was found in only 22.6% of the sample, most commonly among individuals who were transitioning to PIGD predominance. CONCLUSIONS: Regardless of their baseline characteristics, most participants had clear and stable fall risk trajectories over 2 years. Further investigation is required to determine whether interventions to improve gait and balance may improve fall risk trajectories in people with PD.en_US
dc.description.sponsorshipSupported by the Davis Phinney Foundation, the Parkinson's Disease Foundation, National Institutes of Health (NIH) (grant nos. NIH R01 NS077959 and NIH UL1 TR000448), the Massachusetts and Utah Chapters of the American Parkinson Disease Association (APDA), the Greater St Louis Chapter of the APDA, and the APDA Center for Advanced Research at Washington University. (Davis Phinney Foundation; Parkinson's Disease Foundation; NIH R01 NS077959 - National Institutes of Health (NIH); NIH UL1 TR000448 - National Institutes of Health (NIH); Utah Chapter of the American Parkinson Disease Association (APDA); Greater St Louis Chapter of the APDA; APDA Center for Advanced Research at Washington University; Massachusetts Chapter of the American Parkinson Disease Association (APDA))en_US
dc.format.extentp. 372 - 379en_US
dc.languageEnglish
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofArchives Of Physical Medicine And Rehabilitation
dc.relation.isversionofhttps://doi.org/10.1016/j.apmr.2015.10.105
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectRehabilitationen_US
dc.subjectSport sciencesen_US
dc.subjectAccidental fallsen_US
dc.subjectGaiten_US
dc.subjectLongitudinal studiesen_US
dc.subjectParkinson diseaseen_US
dc.subjectRisken_US
dc.subjectRandomized controlled trialen_US
dc.subjectTai Chien_US
dc.subjectExerciseen_US
dc.subjectAccidental fallsen_US
dc.subjectGaiten_US
dc.subjectLongitudinal studiesen_US
dc.subjectParkinson diseaseen_US
dc.subjectRehabilitationen_US
dc.subjectRisken_US
dc.subjectAgeden_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectRisk factorsen_US
dc.subjectClinical sciencesen_US
dc.subjectHuman movement and sports scienceen_US
dc.subjectPublic health and health servicesen_US
dc.subjectRehabilitationen_US
dc.titleTwo-year trajectory of fall risk in people with Parkinson disease: a latent class analysisen_US
dc.typeArticleen_US
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusPublisheden_US


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