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dc.contributor.authorLiu, Ching-Tien_US
dc.contributor.authorYuan, Shinshengen_US
dc.contributor.authorLi, Ker-Chauen_US
dc.date.accessioned2012-01-11T16:08:10Z
dc.date.available2012-01-11T16:08:10Z
dc.date.copyright2008
dc.date.issued2009-2
dc.identifier.citationLiu, Ching-Ti, Shinsheng Yuan, Ker-Chau Li. "Patterns of co-expression for protein complexes by size in Saccharomyces cerevisiae" Nucleic Acids Research 37(2): 526-532. (2009)
dc.identifier.issn1362-4962
dc.identifier.urihttps://hdl.handle.net/2144/3096
dc.description.abstractMany successful functional studies by gene expression profiling in the literature have led to the perception that profile similarity is likely to imply functional association. But how true is the converse of the above statement? Do functionally associated genes tend to be co-regulated at the transcription level? In this paper, we focus on a set of well-validated yeast protein complexes provided by Munich Information Center for Protein Sequences (MIPS). Using four well-known large-scale microarray expression data sets, we computed the correlations between genes from the same complex. We then analyzed the relationship between the distribution of correlations and the complex size (the number of genes in a protein complex). We found that except for a few large protein complexes, such as mitochondrial ribosomal and cytoplasmic ribosomal proteins, the correlations are on the average not much higher than that from a pair of randomly selected genes. The global impact of large complexes on the expression of other genes in the genome is also studied. Our result also showed that the expression of over 85% of the genes are affected by six large complexes: the cytoplasmic ribosomal complex, mitochondrial ribosomal complex, proteasome complex, F0/F1 ATP synthase (complex V) (size 18), rRNA splicing (size 24) and H+- transporting ATPase, vacular (size 15).en_US
dc.description.sponsorshipNational Science Foundation (DMS0201005, DMS0406091, DMS-0707160); MIB; Institute of Statistical Science; Academia Sinica (NSC95-3114-P-002-005-Y, NSC97-2627-P-001-003)en_US
dc.language.isoen
dc.publisherNucleic Acids Researchen_US
dc.rightsCopyright 2008 Liu, Ching-Ti, Shinsheng Yuan, Ker-Chau Li. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/uk/
dc.titlePatterns of Co-Expression for Protein Complexes by Size in Saccharomyces Cerevisiaeen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/nar/gkn972
dc.identifier.pmid19056822
dc.identifier.pmcid2632914


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Copyright 2008 Liu, Ching-Ti, Shinsheng Yuan, Ker-Chau Li. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2008 Liu, Ching-Ti, Shinsheng Yuan, Ker-Chau Li. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.