The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjögren-like disease
MetadataShow full item record
Sjogren's syndrome (SS) is a chronic, multisystem inflammatory disorder of multifactorial etiology resulting in loss of secretory function in the exocrine glands including salivary and lacrimal. Even though the pathophysiology progression of SS has been subject to great amount of research, the roles of different mechanisms remain inconclusive. The main dogma is that immune system pathology drives SS; however, there is no straightforward pathogenesis theory as there are multiple autoantibodies and changing proportions of different T-cell subsets with the progression of the disease along with many other different contributors. Interestingly, increasing evidence points to structural defects, including defective E-cadherin adhesion, to be involved in the etiology of SS. Recently, the Hippo signaling pathway has emerged as one of the main pathways regulating size of the organs and proliferation/ differentiation of cells, in part via interaction with E-cadherin junctions. Despite this, the role of Hippo signaling in the ... [TRUNCATED]
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Endodontics).Includes bibliographic references: leaves 41-49.
RightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.