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dc.contributor.authorWang, Lien_US
dc.date.accessioned2018-09-18T15:34:42Z
dc.date.available2018-09-18T15:34:42Z
dc.date.issued2004
dc.date.submitted2004
dc.identifier.other(OCoLC)57409637
dc.identifier.otherb25360772
dc.identifier.urihttps://hdl.handle.net/2144/31302
dc.descriptionThesis (D.Sc.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004 (Periodontology and Oral Biology).en_US
dc.descriptionIncludes bibliography (leaves 165-186).en_US
dc.description.abstractMucins play an important protective and lubricative function in the oral cavity. They protect hard and soft tissues from desiccation, mechanical abrasion and exogenous insults. These functions are related to the structural properties of the mucin glycoproteins. The major high molecular weight mucin in salivary secretions has been identified as the MUC5B gene product, which is a large secreted gel-forming mucin. The major low molecular weight mucin in salivary secretions has been identified as the MUC7 gene product, which is a small secreted mucin. Another class of mucin molecules, the membrane-bound mucins, is structurally and functionally distinct from MUC5B and MUC7. Two of the membrane-bound mucins, MUC1 and MUC4, are expressed in all major human salivary glands as well as in buccal epithelial cells. The secreted forms of these mucins are also found at low levels in saliva. The aims of this study were: 1) to confirm the expression of membrane-bound mucin MUC1 in oral epithelial cells, 2) to determine whether the membrane-bound mucin MUC1 can form complexes with the secreted mucin MUC5B and to localize the MUC1 binding sites on the MUC5B polypeptide backbone and 3) to identify other proteins from a salivary protein pool which can form heterotypic complexes with MUC1. [TRUNCATED]en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.en_US
dc.subjectMucinsen_US
dc.titleMUC1 expression and molecular interactions in the oral cavityen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameDoctor of Science in Dentistryen_US
etd.degree.leveldoctoralen_US
etd.degree.disciplinePeriodontology and Oral Biologyen_US
etd.degree.grantorBoston Universityen_US


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