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dc.contributor.authorBae, J.en_US
dc.contributor.authorAwad, L.N.en_US
dc.contributor.authorLong, A.en_US
dc.contributor.authorO'Donnell, K.en_US
dc.contributor.authorHendron, K.en_US
dc.contributor.authorHolt, K.G.en_US
dc.contributor.authorEllis, T.D.en_US
dc.contributor.authorWalsh, C.J.en_US
dc.date2018-01-11
dc.date.accessioned2018-10-18T17:51:42Z
dc.identifier.citationJ Bae, LN Awad, A Long, K O'Donnell, K Hendron, KG Holt, TD Ellis, CJ Walsh. "Biomechanical mechanisms underlying exosuit-induced improvements in walking economy after stroke." Journal of Experimental Biology,
dc.identifier.issn0022-0949
dc.identifier.urihttps://hdl.handle.net/2144/31479
dc.description.abstractStroke-induced hemiparetic gait is characteristically asymmetric and metabolically expensive. Weakness and impaired control of the paretic ankle contribute to reduced forward propulsion and ground clearance—walking subtasks critical for safe and efficient locomotion. Targeted gait interventions that improve paretic ankle function after stroke are therefore warranted. We have developed textile-based, soft wearable robots that transmit mechanical power generated by off-board or body-worn actuators to the paretic ankle using Bowden cables (soft exosuits) and have demonstrated the exosuits can overcome deficits in paretic limb forward propulsion and ground clearance, ultimately reducing the metabolic cost of hemiparetic walking. This study elucidates the biomechanical mechanisms underlying exosuit-induced reductions in metabolic power. We evaluated the relationships between exosuit-induced changes in the body center of mass (COM) power generated by each limb, individual joint powers, and metabolic power. Compared to walking with an exosuit unpowered, exosuit assistance produced more symmetrical COM power generation during the critical period of the step-to-step transition (22.4±6.4% more symmetric). Changes in individual limb COM power were related to changes in paretic (R2= 0.83, P= 0.004) and nonparetic (R2= 0.73, P= 0.014) ankle power. Interestingly, despite the exosuit providing direct assistance to only the paretic limb, changes in metabolic power were related to changes in nonparetic limb COM power (R2= 0.80, P= 0.007), not paretic limb COM power (P> 0.05). These findings provide a fundamental understanding of how individuals poststroke interact with an exosuit to reduce the metabolic cost of hemiparetic walking.en_US
dc.publisherCompany of Biologistsen_US
dc.relation.ispartofJournal of Experimental Biology
dc.subjectBiologyen_US
dc.subjectGait biomechanicsen_US
dc.subjectGait energeticsen_US
dc.subjectPost-stroke gaiten_US
dc.subjectRoboticsen_US
dc.subjectStroke rehabilitationen_US
dc.subjectExoskeletonen_US
dc.subjectPhysiologyen_US
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectTo-step transitionsen_US
dc.subjectFunctional electrical-stimulationen_US
dc.subjectGait following strokeen_US
dc.subjectAnkle-foot orthosisen_US
dc.subjectCenter-of-massen_US
dc.subjectEnergy-costen_US
dc.subjectIndividual limbsen_US
dc.subjectHemiparetic gaiten_US
dc.subjectMetabolic costen_US
dc.subjectPush-offen_US
dc.subjectBiological sciencesen_US
dc.subjectMedical and health sciencesen_US
dc.titleBiomechanical mechanisms underlying exosuit-induced improvements in walking economy after strokeen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1242/jeb.168815
dc.description.embargo2019-03-01
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusAccepteden_US
dc.identifier.orcid0000-0002-0159-8011 (Awad, LN)


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