The effect of hepatic fibrosis on T2 value in a mouse model at 3T MRI scanner
Al Sharif, Roaa
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PURPOSE: To correlate spin- spin relaxation time (T2) measurements with degree of hepatic fibrosis of ex vivo murine liver specimens at 3T MRI scanner. MATERIALS AND METHODS: The protocol and procedures were approved by The Institutional Animal Care and Use Committee (IACUC). Sixteen male, six week old C578L/6 mice were divided into two groups, a control group (n=1), which was provided normal food, and for liver fibrosis induction an experimental group (n=15), were provided a 0.1% 3,5-diethoxycarbonyl-1 ,4-dihydrocollidine (DOC) to induce liver fibrosis. Exvivo liver specimens were scanned using 3 T MRI scanner. Multi- echo spin-echo sequence was used to perform T2 map. Hematoxylin-eosin with Masson's trichrome staining was performed in liver specimens. Repeated t-test paired sample was used. RESULTS: Increasing the degree of hepatic fibrosis was seen to decrease liver T2 values. CONCLUSION: In this model, liver fibrosis was detected with T2 MR Imaging; the degree of hepatic fibrosis was correlated with the degree of decrease in T2 measurements.
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