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dc.contributor.authorAl Sharif, Roaaen_US
dc.date.accessioned2018-10-25T12:44:00Z
dc.date.issued2012
dc.date.submitted2012
dc.identifier.otherb38091367
dc.identifier.urihttps://hdl.handle.net/2144/31497
dc.descriptionThesis (M.A.)--Boston Universityen_US
dc.descriptionPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.en_US
dc.description.abstractPURPOSE: To correlate spin- spin relaxation time (T2) measurements with degree of hepatic fibrosis of ex vivo murine liver specimens at 3T MRI scanner. MATERIALS AND METHODS: The protocol and procedures were approved by The Institutional Animal Care and Use Committee (IACUC). Sixteen male, six week old C578L/6 mice were divided into two groups, a control group (n=1), which was provided normal food, and for liver fibrosis induction an experimental group (n=15), were provided a 0.1% 3,5-diethoxycarbonyl-1 ,4-dihydrocollidine (DOC) to induce liver fibrosis. Exvivo liver specimens were scanned using 3 T MRI scanner. Multi- echo spin-echo sequence was used to perform T2 map. Hematoxylin-eosin with Masson's trichrome staining was performed in liver specimens. Repeated t-test paired sample was used. RESULTS: Increasing the degree of hepatic fibrosis was seen to decrease liver T2 values. CONCLUSION: In this model, liver fibrosis was detected with T2 MR Imaging; the degree of hepatic fibrosis was correlated with the degree of decrease in T2 measurements.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.titleThe effect of hepatic fibrosis on T2 value in a mouse model at 3T MRI scanneren_US
dc.typeThesis/Dissertationen_US
dc.description.embargo2031-01-01
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineRadiologyen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.barcode11719026843112
dc.identifier.mmsid99185398580001161


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