Comparing and contrasting different treatment modalities of sickle cell disease
Battle, Charity Michelle
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Sickle cell disease (SCD) is an autosomal recessive disorder affecting over 70,000 people in the United States. Following deoxygenation, red blood cells become deformed and appear in the characteristic sickle-shape. This change in protein structure leads to vasa-occlusive episodes, which may result in a variety of clinical manifestation including, but not limited to, painful crisis, stroke, acute chest syndrome, and/or splenic infarct. Due to the diversity of symptoms, management of this disease can be complex.In SCD, some of the treatment modalities involve controlling infections, pain management, fetal hemoglobin stimulation, blood transfusion, hematopoietic stem cell transplant and potentially gene therapy. This paper discusses the risk and benefits of these different treatment modalities.
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