Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • College of Arts and Sciences
    • Psychological and Brain Sciences
    • CAS: Psychological and Brain Sciences: Scholarly Papers
    • View Item
    •   OpenBU
    • College of Arts and Sciences
    • Psychological and Brain Sciences
    • CAS: Psychological and Brain Sciences: Scholarly Papers
    • View Item

    Genetic Influences on Attention Deficit Hyperactivity Disorder Symptoms from Age 2 to 3: A Quantitative and Molecular Genetic Investigation

    Thumbnail
    Date Issued
    2010-12-1
    Publisher Version
    10.1186/1471-244X-10-102
    Author(s)
    Ilott, Nicholas E
    Saudino, Kimberly J
    Asherson, Philip
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Permanent Link
    https://hdl.handle.net/2144/3152
    Citation (published version)
    Ilott, Nicholas E, Kimberly J Saudino, Philip Asherson. "Genetic influences on attention deficit hyperactivity disorder symptoms from age 2 to 3: A quantitative and molecular genetic investigation" BMC Psychiatry 10:102. (2010)
    Abstract
    BACKGROUND. A twin study design was used to assess the degree to which additive genetic variance influences ADHD symptom scores across two ages during infancy. A further objective in the study was to observe whether genetic association with a number of candidate markers reflects results from the quantitative genetic analysis. METHOD. We have studied 312 twin pairs at two time-points, age 2 and age 3. A composite measure of ADHD symptoms from two parent-rating scales: The Child Behavior Checklist/1.5 - 5 years (CBCL) hyperactivity scale and the Revised Rutter Parent Scale for Preschool Children (RRPSPC) was used for both quantitative and molecular genetic analyses. RESULTS. At ages 2 and 3 ADHD symptoms are highly heritable (h2 = 0.79 and 0.78, respectively) with a high level of genetic stability across these ages. However, we also observe a significant level of genetic change from age 2 to age 3. There are modest influences of non-shared environment at each age independently (e2 = 0.22 and 0.21, respectively), with these influences being largely age-specific. In addition, we find modest association signals in DAT1 and NET1 at both ages, along with suggestive specific effects of 5-HTT and DRD4 at age 3. CONCLUSIONS. ADHD symptoms are heritable at ages 2 and 3. Additive genetic variance is largely shared across these ages, although there are significant new effects emerging at age 3. Results from our genetic association analysis reflect these levels of stability and change and, more generally, suggest a requirement for consideration of age-specific genotypic effects in future molecular studies.
    Rights
    Copyright 2010 Ilott et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Collections
    • CAS: Psychological and Brain Sciences: Scholarly Papers [232]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help