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dc.contributor.authorCheng, Kari Yi Hanen_US
dc.date.accessioned2018-10-25T12:47:14Z
dc.date.issued2012
dc.date.submitted2012
dc.identifier.otherb38091392
dc.identifier.urihttps://hdl.handle.net/2144/31526
dc.descriptionThesis (M.A.)--Boston Universityen_US
dc.descriptionPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.en_US
dc.description.abstractA previous study conducted by Kornetsky et al. (2010) showed that the stimulation of the mesencephalic reticular formation (MRF) along with low intensity stimulation of the medial forebrain (MFB) produces effects that resemble that of an opioid antagonist. Specifically, simultaneous stimulation was found to attenuate the analgesic effects of morphine. It was hypothesized that this phenomenon could be due to the release of an endogenous opioid receptor competitive antagonist (EO RCA) during the simultaneous stimulation of both the reward and nociceptive areas. To investigate this hypothesis, the previous experiment was repeated but substituting morphine with LY235959, a non-opioid analgesic that is a competitive NMDA receptor antagonist. To determine whether the effects of concurrent stimulation pertain only to opioid analgesics, LY235959 was administered along with MRF-MFB stimulation to observe if the analgesic effects of LY235959 could also be reversed by concurrent stimulation. The experimental results of this research show that LY235959 alone exhibits dose-dependent analgesic effects. However, when L Y235959 is administered concurrently with MRF-MFB stimulation, the analgesic effects are reversed, which suggests that concurrent stimulation can reverse the effects of non-opioid analgesic agents. The results of this research thus do not provide sufficient evidence to support the hypothesis that EO RCA was released during simultaneous stimulation. Specifically, the results show that combined stimulation of MRF-MFB has effects that are not limited to the opioid analgesic system.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.titleThe effect of LY235959 and rewarding stimulation on intracranial nociceptionen_US
dc.typeThesis/Dissertationen_US
dc.description.embargo2031-01-01
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplinePsychiatryen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.barcode11719026843179
dc.identifier.mmsid99185391570001161


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