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dc.contributor.authorDirksen, Courtney L.en_US
dc.contributor.authorHoward, Julie A.en_US
dc.contributor.authorCronin-Golomb, Aliceen_US
dc.contributor.authorOscar-Berman, Marleneen_US
dc.date.accessioned2012-01-11T17:18:52Z
dc.date.available2012-01-11T17:18:52Z
dc.date.issued2006
dc.identifier.citationDirksen, Courtney L, Julie A Howard, Alice Cronin-Golomb, Marlene Oscar-Berman. "Patterns of prefrontal dysfunction in alcoholics with and without Korsakoff's syndrome, patients with Parkinson's disease, and patients with rupture and repair of the anterior communicating artery" Neuropsychiatric Disease and Treatment 2(3): 327-339. (2006)
dc.identifier.issn1178-2021
dc.identifier.urihttps://hdl.handle.net/2144/3159
dc.description.abstractThis study compared patterns of frontal-lobe dysfunction in alcoholics with Korsakoff's syndrome (KS: n = 9), non-Korsakoff alcoholics (AL: n = 28), patients with Parkinson's disease (PD: n = 18), and patients with rupture and repair of the anterior communicating artery (ACoA: n = 4) relative to healthy non-neurological control (NC) participants (n = 70). The tests administered were sensitive to functions of dorsolateral prefrontal and orbito-frontal subsystems. Measures included perseverative errors on the Wisconsin Card Sorting Test (WCST-pe), errors on object alternation (OA), errors on Trails B, number of words generated on the Controlled Oral Word Association Test (COWAT), and number of categories completed on the WCST (WCST-cc). KS patients were as impaired as AL participants on orbitofrontal measures and, on dorsolateral prefrontal measures, were impaired relative to AL participants, whose performance did not differ from controls. Patients with PD also were impaired on tests of orbitofrontal and dorsolateral prefrontal functioning but to a lesser extent than the KS patients. Moreover, most of the PD deficits were driven by the impaired performance of patients whose initial symptoms were on the right side of the body. The ACoA patients were significantly impaired on tests of orbitofrontal but not dorsolateral prefrontal functioning relative to the control group. Together, the results confirm different patterns of frontal-system impairments in patient groups having compromised frontal lobe functioning consequent to varying etiologies.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism grants (F31-AA05557, R37–AA07112, K05–AA00219); Medical Research Service of the U.S. Department of Veterans Affairs.en_US
dc.language.isoenen_US
dc.publisherDove Medical Pressen_US
dc.titlePatterns of Prefrontal Dysfunction in Alcoholics with and without Korsakoff's Syndrome, Patients with Parkinson's Disease, and Patients with Rupture and Repair of the Anterior Communicating Arteryen_US
dc.typeArticleen_US
dc.identifier.pmid19412479
dc.identifier.pmcid2671822


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