Differential expression of mucin genes in human salivary glands
Henry M Goldman School of Dental Medicine (Boston University)
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Mucins are described as high molecular weight glycoproteins, which are considered to be the major protein components for the body mucus. Mucins are secreted by epithelial surfaces that line the reproductive , respiratory, gastrointestinal tracts. This lining or coat cover can protect many vital structures in the oral cavity, digestive and respiratory systems. The two major mucus secreting salivary glands, the sublingual and submandibular glands, are capable of producing mucins although little is known about differences in the type of mucins and amount that might be secreted by each gland. Therefore, the purpose of our research was to compare the differential expression patterns of the mucins MUC 1, MUC4 , MUC5B , MUC7 and MUC 19 from the two major mucus secreting salivary glands in the oral cavity. This investigation was divided in two stages. ln the first stage of this study we used conventional RT-PCR to assess the differential qualitative expression patterns for MUC I, MUC4, MUC5B, MUC7 and MUC 19 in the sub lingual and submandibular glands. The results of the first stage showed MUC5B, MUC4 and MUC7 to be more abundantly expressed in the sublingual gland than in the submandibular gland, and MUC 1 and MUC 19 to be more predominantly expressed in the submandibular gland compared to sublingual gland. [TRUNCATED]
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact email@example.com.Thesis (MSD)--Boston University, Goldman School of Dental Medicine, 2007 (Dept. of Periodontology and Oral Biology).Includes bibliographical references: leaves 42-53.
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