Explorative investigation of MUC7 expression in oral tissues
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Mucus serves several protective functions within the human body , such as hydrating the epithelium and trapping foreign substances for removal. The key components of mucus are glycoproteins which are also known as mucins. Mucins are currently defined as proteins whose mass consists 50% or more of O-linked oligosaccharides. There are two forms of mucins , membrane-associated mucins and secreted mucins. The two forms vary in their structure and their function. Membrane-associated mucins are hydrophobic and therefore do not form oligomeric complexes. However, secreted mucins , also known as gel-forming mucins , are commonly found in oligomeric complexes with molecular weights greater than 40 million Daltons. Subunits in these oligomers are linked to one another via disulfide bonds. Secreted mucins give mucus its sticky consistency and help it to serve as a first line of defense in the body. While membrane-associated and secreted mucins vary in both structure and function , they share several common structural features . MUC7 is small secreted mucin , which exists solely as a monomer, and it is predominately expressed in the submandibular and sublingual glands. It has different functions, both immune and non-immune. It is thought that MUC7 may exist in other oral tissues to perform similar functions or different ones. Thus the aim of this study is to investigate the validity of this hypothesis.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (MSD)--Boston University, Henry M. Goldman School of Dental Medicine (Prosthodontics).Includes bibliographical references: leaves 30-40.
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