A comparative study of local cortisone administrations to that of systemic in buccal mucosa carcinogenesis
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Sixty male golden Syrian hamsters (Lakeview Hamster Colony, Newfield, New Jersey), three months of age, were divided into five equal experimental groups and fed a standard laboratory diet. The animals of Group I (Control) received triweekly application of heavy mineral oil (USP) into the right buccal pouch with a No. 4 camel's hair brush for 16 weeks. The animals of Groups II, III, IV, and V received triweekly topical application of 7-12-dimethylbenzanthracene (DMBA) at a concentration of 0.5% w/v in heavy mineral oil (USP), according to the technic of Salley (J. Dent. Res., 33:253-262, 1954). In this manner about 0.2 ml. of solution was deposited in the pouch at each painting, containing 1 mg. of DMBA. Animals in Group III, in addition to the application of DMBA, received a triweekly S.C. , injection into the groin of 2.5 mg. of cortisone acetate (Premo Pharmaceutical Laboratory, Inc., Hackensack, New Jersey). [TRUNCATED]
Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1972. (Oral surgery)Bibliography included.
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