Immunization enhances inflammation & tissue destruction in response to porphyromonas gingvalis
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Porphyromonas gingivalis, a gram-negative anaerobe, is implicated in the etiology of periodontal disease. Infections with P. gingivalis result in the activation of inflammatory cells that can progress, if not treated, to destruction of the periodontal ligament and alveolar bone leading to tooth loss. The purpose of this study was to investigate the effects of P. gingivalis immunity on periodontal disease, in other words the effects of acquired immunity on periodontal disease. For this purpose, wild type (CD-1), 8-weeks-old mice were immunized by injecting P.g381 subcutaneously in the back once a week for three weeks. The calvaria of immunized and sham immunized mice were then challenged with live P .gingivalis. Mice were sacrificed on day-5 and day-8 after injection and the calvaria was then dissected and analyzed histologically. On day-5 and 8, immunization significantly increased and prolonged the formation of a PMN and mononuclear cell infiltrate (P<0.05), with a significantly lower fibroblasts (P<0.05). These results indicate that acquired immunity activation by P. gingivalis leads to a significant increase in the inflammatory response. [TRUNCATED]
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (MSD)--Boston University, Henry M. Goldman School of Dental Medicine, 2005 (Periodontics).Includes bibliographical references: leaves 48-53.
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