Immunohistochemical investigation of TGF-beta expression in posterior gingival tissue of phenytoin treated mice
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Patients undergoing phenytoin treatment may develop gingival overgrowth as a side effect. During drug-induced gingival overgrowth (DIGO), epithelial tissues will go through epithelial to mesenchymal transition (EMT) to become more like cormective tissue. EMT is associated with fibrosis as well as cancer. Objectives: The objective of this experiment is to investigate TGF-beta expression in posterior gingival epithelial and comective tissues of phenytoin treated mice in order to assess for a correlation between TGF-beta expression and gingival overgrowth in mice. The overall hypothesis is that since the gingival overgrowth does not happen extensively in the posterior gingival tissues, TGF-beta expression may not be highly expressed in the posterior gingival tissues. This study is a part of a larger prqiect to replicate human Phenytoin-induced gingival overgrowth in a mouse model in order to study and ... [TRUNCATED]
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact email@example.com.Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2015 (Department of Molecular and Cell Biology).Includes bibliography: leaves 35-44.
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