A comparative study of bacterial endotoxin concentration and proteolytic enzyme activity in human dental plaque
Jacobson, Irving W.
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Endotoxin concentrations and proteolytic enzyme activities were measured in the dental plaque of four groups of patients. Group A consisted of institutionalized mongoloids, Group B were home-bound mongoloids, Group C were non-mongoloid retardates, and Group D were normal patients. The Limulus lysate technique, developed by Levin and Bang (79) and modified by Reinhold and Fine (112) was used to measure endotoxin. Proteolytic enzyme activity was determined with a method developed by Stallard and utilized by Hiep (58). The values obtained were statistically analyzed, interpreted, and discussed. The difference in enzyme activity between institutionalized mongoloids and normal patients was highly significant (p( .05). · The endotoxin concentration was also found to be higher, at a significant 1 evel (p< .05), between these two groups. Within the . home-bound mongoloid group, the enzyme activity and ·periodontal condition were significantly correlated (p< .001). Grouping all individuals together, enzyme activity was correlated with periodontal condition (p(< .001). The enzyme activity also correlated to endotoxin concentration at a high level of significance (p< .001). The results support the growing evidence for a role played by endotoxin and proteolytic enzymes in periodontal disease.
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (M.Sc.D.)--Boston University, School of Graduate Dentistry, 1973.Bibliography included.
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