Transcription regulation of cathepsin K controlled by bone resorption related cytokines
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Osteoclasts function as bone and cartilage-resorbing cells to modulate bone formation and metabolism. They posses a highly specialized proton generating mechanism for the rapid dissolution of bone mineral and secrete collagenases, cathepsin K and other hydrolyses active in the degradation of bone matrix proteins. To date, several cytokines have been implicated in osteoclast formation and activity. Some cytokines, including IL-1a, induce bone resorption whereas the others, such as IFN-y, inhibit bone resorption. It is possible that cytokines may control physiological and pathological bone resorption through the regulation of osteoclast gene expression including cathepsin K. Cathepsin K is abundantly and selectively expressed in osteoclast, and is a key protease responsible for matrix protein degradation in normal bone remodeling as well as in pathological processes, such as periodontal disease and osteoporosis. lnterferon-y (IFN-y) is a glycoprotein produced by activated lymphocyte and natural killer cells and has multiple biologic effects, including antiviral, antitumor, and cell growth inhibitory activities. Like many other cytokines, IFN-y also functions in bone metabolism. IFN-y inhibits osteoclastic bone resorption, but the mechanism responsible for this inhibition is unknown. IL-1a is pluripotent cytokine produced by monocytes/macrophages that has various effects on a wide variety of cells including osteoclast. I L-1 a is the most potent osteoclast-activating factor that ... [TRUNCATED]
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact email@example.com.Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 1999 (Pediatric Dentistry).Includes bibliographical references (leaves 68-79).
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