Role of apoptosis in inflammatory processes: involvement of secreted frizzled-related protein 1 (SFRP1)
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Porphyromonas gingivalis (P. gingivalis) is implicated as a major pathogen in periodontitis, a common infectious disease characterized by inflammation and destruction of periodontal tissues. Wound healing is a complex cascade of events which diminishes the size of the wound and reestablishes tissue integrity through three overlapping phases: inflammation, proliferation, and maturation and remodeling. The inflammatory phase is an essential phase of wound healing . Apoptosis, a mechanism of programmed cell death, is critically important in many biological processes for the maintenance of tissue integrity and homeostasis. S~creted frizzled-related protein 1 (SFRP 1) modulates apoptosis in different cell types. On the basis of this evidence, we hypothesize that SFRPl plays an important role in the regulation of inflammation in periodontitis and wound healing. The aims in this study were (1) to evaluate the role of SFRPl in vivo in a mouse model of periodontitis and (2) to investigate the role of SFRP 1 in vivo in a mouse model of wound healing. [TRUNCATED]
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact firstname.lastname@example.org.Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2007 (Periodontology and Oral Biology).Includes bibliography: (leaves 149-177).
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