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dc.contributor.authorSalciccioli, Justin Danielen_US
dc.date.accessioned2018-11-07T16:00:27Z
dc.date.issued2012
dc.date.submitted2012
dc.identifier.otherb38092098
dc.identifier.urihttps://hdl.handle.net/2144/32052
dc.descriptionThesis (M.A.)--Boston University, 2012.en_US
dc.descriptionPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.en_US
dc.description.abstractRecent evidence has suggested that vitamin D may modulate innate immune function. We performed a prospective, observational investigation to assess the prevalence of vitamin D deficiency in adult critically ill patients with sepsis. Subjects were categorized by baseline 25-hydroxyvitamin D [25(0H)D]: Deficient: < 20 ng/ml, Insufficient: 21-29 ng/ml, or Normal: > 29 ng/ml. A total of 39 subjects were enrolled in the study. 25(0H)D deficiency is common with 23/39 (59%) of subjects either deficient or insufficient. In-hospital mortality was 15% (6/39) and 5/6 (83%) of the subjects who expired were 25(0H)D insufficient. There were modest differences in severity of illness across 25(0H)D categories (SAPS 3: p = 0.01) and statistically significant inverse associations between 25(0H)D and markers of inflammation (IL-6: p = 0.04; TN F-a: p = 0.03) and vascular endothelial dysfunction (E-selectin: p = 0.05). There is a high prevalence of vitamin D deficiency or insufficiency in critically ill patients with sepsis and an inverse association between vitamin D and inflammation and vascular endothelial dysfunction. Future studies should assess the causal relationship between vitamin D and inflammation and outcomes from sepsis.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.subjectVitamin Den_US
dc.subjectSepsisen_US
dc.subjectCritical illnessen_US
dc.titleVitamin D status in critically ill patients with sepsisen_US
dc.typeThesis/Dissertationen_US
dc.description.embargo2031-01-02
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedicineen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.barcode11719026843351
dc.identifier.mmsid99185409790001161


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