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dc.contributor.authorBastiani, Micheleen_US
dc.contributor.authorLiu, Libinen_US
dc.contributor.authorHill, Michelle M.en_US
dc.contributor.authorJedrychowski, Mark P.en_US
dc.contributor.authorNixon, Susan J.en_US
dc.contributor.authorLo, Harriet P.en_US
dc.contributor.authorAbankwa, Danielen_US
dc.contributor.authorLuetterforst, Roberten_US
dc.contributor.authorFernandez-Rojo, Manuelen_US
dc.contributor.authorBreen, Michael R.en_US
dc.contributor.authorGygi, Steven P.en_US
dc.contributor.authorVinten, Jorgenen_US
dc.contributor.authorWalser, Piers J.en_US
dc.contributor.authorNorth, Kathryn N.en_US
dc.contributor.authorHancock, John F.en_US
dc.contributor.authorPilch, Paul F.en_US
dc.contributor.authorParton, Robert G.en_US
dc.date.accessioned2012-01-11T21:40:11Z
dc.date.available2012-01-11T21:40:11Z
dc.date.copyright2009
dc.date.issued2009-06-22
dc.identifier.citationBastiani, Michele, Libin Liu, Michelle M. Hill, Mark P. Jedrychowski, Susan J. Nixon, Harriet P. Lo, Daniel Abankwa, Robert Luetterforst, Manuel Fernandez-Rojo, Michael R. Breen, Steven P. Gygi, Jorgen Vinten, Piers J. Walser, Kathryn N. North, John F. Hancock, Paul F. Pilch, Robert G. Parton. "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes" Journal of Cell Biology 185(7): 1259-1273. (2009)
dc.identifier.issn1540-8140
dc.identifier.urihttps://hdl.handle.net/2144/3220
dc.description.abstractPolymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds to C kinase (SRBC)/Cavin-3, and muscle-restricted coiled-coil protein (MURC)/Cavin-4, forms a multiprotein complex that associates with caveolae. This complex can constitutively assemble in the cytosol and associate with caveolin at plasma membrane caveolae. Cavin-1, but not other cavins, can induce caveola formation in a heterologous system and is required for the recruitment of the cavin complex to caveolae. The tissue-restricted expression of cavins suggests that caveolae may perform tissue-specific functions regulated by the composition of the cavin complex. Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein.en_US
dc.description.sponsorshipNational Health and Medical Research Council of Australia; Australian Research Council; National Institutes of Health (DK30425, DK56935, DK07201); Pilot and Feasibility award from the Boston Obesity Nutrition Research Center (DK046200); Swiss National Science Foundation (PAOOA-111446, PAOOA-109094)en_US
dc.language.isoen
dc.publisherThe Rockefeller University Pressen_US
dc.rightsCopyright 2009 Bastiani et al.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/
dc.titleMURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexesen_US
dc.typeArticleen_US
dc.identifier.doi10.1083/jcb.200903053
dc.identifier.pmid19546242
dc.identifier.pmcid2712963


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