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dc.contributor.authorSipe, J. D.en_US
dc.contributor.authorMartel-Pelletier, J.en_US
dc.contributor.authorOtterness, I. G.en_US
dc.contributor.authorPelletier, J.-P.en_US
dc.date.accessioned2012-01-11T21:40:11Z
dc.date.available2012-01-11T21:40:11Z
dc.date.copyright1994
dc.date.issued1994
dc.identifier.citationSipe, J. D., J. Martel-Pelletier, I. G. Otterness, J.-P. Pelletier. "Cytokine Reduction in the Treatment of Joint Conditions" Mediators of Inflammation 3(4): 243-256. (1994)
dc.identifier.issn1466-1861
dc.identifier.urihttps://hdl.handle.net/2144/3222
dc.description.abstractThe destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradative enzymes, and by inhibition of reparative processes. The destructive action of cytokines such as interleukin-1, interleukin-6 and tumour necrosis factor-α can be modulated at multiple points associated either with cytokine production or with cytokine action. Potential agents for cytokine reduction include selective anti-cytokine antibodies, anticytokine receptor antibodies, cytokine receptor antagonist proteins, and soluble and chimeric cytokine receptor molecules. Pharmacologic regulation of IL-1 and TNFα remain primary targets for treatment of arthritis, and results of early clinical trials are promising. However, the results of long-term clinical trials will be required to support the value of anti-cytokine therapy in treatment of arthritis.en_US
dc.language.isoen
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.titleCytokine Reduction in the Treatment of Joint Conditionsen_US
dc.typeArticleen_US
dc.identifier.doi10.1155/S0962935194000359
dc.identifier.pmid18472950
dc.identifier.pmcid2367051


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Copyright 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.