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    Use of Selective Serotonin Reuptake Inhibitors and Risk of Re-Operation Due to Post-Surgical Bleeding in Breast Cancer Patients: A Danish Population-Based Cohort Study

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    Copyright 2010 Gärtner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Date Issued
    2010-1-24
    Publisher Version
    10.1186/1471-2482-10-3
    Author(s)
    Gärtner, Rune
    Cronin-Fenton, Deirdre
    Hundborg, Heidi H
    Pedersen, Lars
    Lash, Timothy L
    Sørensen, Henrik Toft
    Kroman, Niels
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    Permanent Link
    https://hdl.handle.net/2144/3261
    Citation (published version)
    Gärtner, Rune, Deirdre Cronin-Fenton, Heidi H Hundborg, Lars Pedersen, Timothy L Lash, Henrik Toft Sørensen, Niels Kroman. "Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: a Danish population-based cohort study" BMC Surgery 10:3. (2010)
    Abstract
    BACKGROUND. Selective serotonin reuptake inhibitors (SSRI) decrease platelet-function, which suggests that SSRI use may increase the risk of post-surgical bleeding. Few studies have investigated this potential association. METHODS. We conducted a population-based study of the risk of re-operation due to post-surgical bleeding within two weeks of primary surgery among Danish women with primary breast cancer. Patients were categorised according to their use of SSRI: never users, current users (SSRI prescription within 30 days of initial breast cancer surgery), and former users (SSRI prescription more than 30 days before initial breast cancer surgery). We calculated the risk of re-operation due to post-surgical bleeding within 14 days of initial surgery, and the relative risk (RR) of re-operation comparing SSRI users with never users of SSRI adjusting for potential confounders. RESULTS. 389 of 14,464 women (2.7%) were re-operated. 1592 (11%) had a history of SSRI use. Risk of re-operation was 2.6% among never users, 7.0% among current SSRI users, and 2.7% among former users. Current users thus had an increased risk of re-operation due to post-operative bleeding (adjusted relative risk = 2.3; 95% confidence interval (CI) = 1.4, 3.9) compared with never users. There was no increased risk of re-operation associated with former use of SSRI (RR = 0.93, 95% CI = 0.66, 1.3). CONCLUSIONS. Current use of SSRI is associated with an increased risk of re-operation due to bleeding after surgery for breast cancer.
    Rights
    Copyright 2010 Gärtner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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