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    • Goldman School of Dental Medicine
    • GSDM: Historical Theses and Dissertations (Open Access)
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    •   OpenBU
    • Goldman School of Dental Medicine
    • GSDM: Historical Theses and Dissertations (Open Access)
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    Resolvin E1 actions on polymorphonuclear neutrophils in diabetes

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    Date Issued
    2010
    Author(s)
    Sima, Corneliu
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    Permanent Link
    https://hdl.handle.net/2144/32698
    Abstract
    Diabetes and periodontal disease exhibit a bidirectional relationship centered on an enhanced inflammatory response manifested both locally and systemically. The observation that hyperglycemia by itself, in the absence of additional inflammatory signals, promotes a proinflammatory environment indicates that diabetes is an independent risk factor for periodontal disease. Leukocyte pre-activation or priming in diabetes has been demonstrated. Excessive ROS release by leukocytes, upregulation of pro-inflammatory mediators and adhesion molecules are characteristic to T2DM-associated low-grade inflammation. However, the mechanisms by which chronic hyperglycemia leads to leukocyte activation are not fully understood. [TRUNCATED]
    Description
    Dissertation (DScD) -- Boston University, Henry M. Goldman School of Dental Medicine, 2010 (Department of Periodontology and Oral Biology).
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    This work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.
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    • GSDM: Historical Theses and Dissertations (Open Access) [177]
    • Dissertations and Theses (1964-2011) [1536]


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