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dc.contributor.authorBohland, Jason W.en_US
dc.contributor.authorWu, Caizhien_US
dc.contributor.authorBarbas, Helenen_US
dc.contributor.authorBokil, Hemanten_US
dc.contributor.authorBota, Mihailen_US
dc.contributor.authorBreiter, Hans C.en_US
dc.contributor.authorCline, Hollis T.en_US
dc.contributor.authorDoyle, John C.en_US
dc.contributor.authorFreed, Peter J.en_US
dc.contributor.authorGreenspan, Ralph J.en_US
dc.contributor.authorHaber, Suzanne N.en_US
dc.contributor.authorHawrylycz, Michaelen_US
dc.contributor.authorHerrera, Daniel G.en_US
dc.contributor.authorHilgetag, Claus C.en_US
dc.contributor.authorHuang, Z. Joshen_US
dc.contributor.authorJones, Allanen_US
dc.contributor.authorJones, Edward G.en_US
dc.contributor.authorKarten, Harvey J.en_US
dc.contributor.authorKleinfeld, Daviden_US
dc.contributor.authorKötter, Rolfen_US
dc.contributor.authorLester, Henry A.en_US
dc.contributor.authorLin, John M.en_US
dc.contributor.authorMensh, Brett D.en_US
dc.contributor.authorMikula, Shawnen_US
dc.contributor.authorPanksepp, Jaaken_US
dc.contributor.authorPrice, Joseph L.en_US
dc.contributor.authorSafdieh, Josephen_US
dc.contributor.authorSaper, Clifford B.en_US
dc.contributor.authorSchiff, Nicholas D.en_US
dc.contributor.authorSchmahmann, Jeremy D.en_US
dc.contributor.authorStillman, Bruce W.en_US
dc.contributor.authorSvoboda, Karelen_US
dc.contributor.authorSwanson, Larry W.en_US
dc.contributor.authorToga, Arthur W.en_US
dc.contributor.authorVan Essen, David C.en_US
dc.contributor.authorWatson, James D.en_US
dc.contributor.authorMitra, Partha P.en_US
dc.date.accessioned2012-01-11T22:26:44Z
dc.date.available2012-01-11T22:26:44Z
dc.date.issued2009-3-27
dc.identifier.citationBohland, Jason W., Caizhi Wu, Helen Barbas, Hemant Bokil, Mihail Bota, Hans C. Breiter, Hollis T. Cline, John C. Doyle, Peter J. Freed, Ralph J. Greenspan, Suzanne N. Haber, Michael Hawrylycz, Daniel G. Herrera, Claus C. Hilgetag, Z. Josh Huang, Allan Jones, Edward G. Jones, Harvey J. Karten, David Kleinfeld, Rolf Kötter, Henry A. Lester, John M. Lin, Brett D. Mensh, Shawn Mikula, Jaak Panksepp, Joseph L. Price, Joseph Safdieh, Clifford B. Saper, Nicholas D. Schiff, Jeremy D. Schmahmann, Bruce W. Stillman, Karel Svoboda, Larry W. Swanson, Arthur W. Toga, David C. Van Essen, James D. Watson, Partha P. Mitra. "A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale" PLoS Computational Biology 5(3): e1000334. (2009)
dc.identifier.issn1553-7358
dc.identifier.urihttps://hdl.handle.net/2144/3291
dc.description.abstractIn this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.en_US
dc.description.sponsorshipW. M. Keck Foundationen_US
dc.language.isoen
dc.publisherPublic Library of Scienceen_US
dc.titleA Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scaleen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pcbi.1000334
dc.identifier.pmid19325892
dc.identifier.pmcid2655718


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