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dc.contributor.authorAllen, Dustinen_US
dc.contributor.authorHuang, Muen_US
dc.contributor.authorMorris, Nathanen_US
dc.contributor.authorChaseling, Georgiaen_US
dc.contributor.authorJay, Ollieen_US
dc.contributor.authorDavis, Scotten_US
dc.date2018-10-24
dc.date.accessioned2018-12-13T13:07:00Z
dc.date.available2018-12-13T13:07:00Z
dc.identifier.citationDustin Allen, Mu Huang, Nathan Morris, Georgia Chaseling, Ollie Jay, Scott Davis. 2018. "Impaired thermoregulatory function during dynamic exercise in multiple sclerosis." Medicine and Science in Sports and Exercise, (Publish Ahead of Print) https://doi.org/10.1249/MSS.0000000000001821
dc.identifier.issn0025-7990
dc.identifier.urihttps://hdl.handle.net/2144/32925
dc.description.abstractINTRODUCTION: Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared to healthy controls (CON) exercising at similar rates of metabolic heat production. METHODS: Sweating and skin blood flow responses were compared between 12 individuals diagnosed with relapsing-remitting MS (9 females, 3 males) and 12 sex-, age-, mass- and BSA-matched healthy controls during a single bout of cycling exercise (rate of metabolic heat production: ~4.5 W/kg) for 60 min in a climate-controlled room (25 °C, 30% RH). RESULTS: Individuals with MS exhibited an attenuated increase in cumulative whole-body sweat loss after 30 min (MS: 72 ± 51; CON: 104 ± 37 g, p=0.04) and 60 min (MS: 209 ± 94; CON: 285 ± 62 g, p=0.02), as well as lower sweating thermosensitivity (MS: 0.49 ± 0.26; CON: 0.86 ± 0.30 mg/cm2/min/°C, p=0.049). Despite evidence for thermoregulatory dysfunction, there were no differences between MS and CON in esophageal or rectal temperatures at 30 or 60 min time points (p>0.05). Cutaneous vasculature responses were also not different in MS compared to CON (p>0.05). CONCLUSION: Taken together, MS blunts sweating responses during exercise while cutaneous vasculature responses are preserved. Altered mechanisms of body temperature regulation in persons with MS may lead to temporary worsening of disease symptoms and limit exercise tolerance under more thermally challenging conditions.en_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.relation.ispartofMedicine and Science in Sports and Exercise
dc.subjectHuman movement and sports scienceen_US
dc.subjectSport sciencesen_US
dc.subjectMultiple sclerosisen_US
dc.titleImpaired thermoregulatory function during dynamic exercise in multiple sclerosisen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1249/MSS.0000000000001821
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Health Sciencesen_US
pubs.publication-statusAccepteden_US


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