A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues
Porco, John A.
Beeler, Aaron B.
MetadataShow full item record
Citation (published version)Han Yueh, Qiwen Gao, John A Porco, Aaron B Beeler. 2017. "A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues." Bioorganic & Medicinal Chemistry, Volume 25, Issue 23, pp. 6197 - 6202 (6). https://doi.org/10.1016/j.bmc.2017.06.010
Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2]-photocycloaddition of 2-(p-methoxyphenyl)-3-hydroxyflavone and cinnamate-derived dipolarophiles. These reactors can be efficiently numbered up to increase throughput two orders of magnitude greater than the corresponding batch reactions.
Published in final edited form as: Bioorg Med Chem. 2017 Dec 1; 25(23): 6197–6202. Published online 2017 Jun 11. doi: [10.1016/j.bmc.2017.06.010]
Showing items related by title, author, creator and subject.
Gervais, Anais; Lazarski, Kiel E.; Porco, John A. (2015-10-02)Herein, we report total syntheses of the tetramethyldihydroxanthene natural product rhodomyrtosone B and the related bis-furan β-triketone natural product rhodomyrtosone A. Nickel-(II)-catalyzed 1,4-conjugate addition of ...
Hayashi, Mikayo; Brown, Lauren E.; Porco, John A. (2016-10)Enantioenriched, polycyclic compounds were obtained from a simple acylphloroglucinol scaffold. Highly enantioselective dearomatization was accomplished using a Trost ligand-palladium(0) complex. A computational DFT model ...
Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes Martin, Véronique I.; Goodell, John R.; Ingham, Oscar J.; Porco, John A.; Beeler, Aaron B. (2014-05-02)We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss ...