Show simple item record

dc.contributor.authorBaskin, Britahny M.en_US
dc.contributor.authorDhonnchadha, Brid A. Nicen_US
dc.contributor.authorDwoskin, Linda P.en_US
dc.contributor.authorKantak, Kathleen M.en_US
dc.date.accessioned2019-02-08T16:12:38Z
dc.date.available2019-02-08T16:12:38Z
dc.date.issued2017-10-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000409895900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationBritahny M Baskin, Brid A Nic Dhonnchadha, Linda P Dwoskin, Kathleen M Kantak. 2017. "Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment." PSYCHOPHARMACOLOGY, Volume 234, Issue 19, pp. 2897 - 2909 (13). https://doi.org/10.1007/s00213-017-4681-y
dc.identifier.issn0033-3158
dc.identifier.issn1432-2072
dc.identifier.urihttps://hdl.handle.net/2144/33299
dc.description.abstractRATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood under a progressive ratio (PR) schedule. Compared to vehicle, chronic atomoxetine treatment during adolescence failed to increase cocaine self-administration under a PR schedule in adult SHR. OBJECTIVES: We determined if enhanced noradrenergic transmission at α2-adrenergic receptors within prefrontal cortex contributes to this neutral effect of adolescent atomoxetine treatment in adult SHR. METHODS: Following treatment from postnatal days 28–55 with atomoxetine (0.3 mg/kg) or vehicle, adult male SHR and control rats from Wistar-Kyoto (WKY) and Wistar (WIS) strains were trained to self-administer 0.3 mg/kg cocaine. Self-administration performance was evaluated under a PR schedule of cocaine delivery following infusion of the α2-adrenergic receptor antagonist idazoxan (0 and 10–56 μg/side) directly into prelimbic cortex. RESULTS: Adult SHR attained higher PR break points and had greater numbers of active lever responses and infusions than WKY and WIS. Idazoxan dose-dependently increased PR break points and active lever responses in SHR following adolescent atomoxetine vs. vehicle treatment. Behavioral changes were negligible after idazoxan pretreatment in SHR following adolescent vehicle or in WKY and WIS following adolescent atomoxetine or vehicle. CONCLUSIONS: α2-Adrenergic receptor blockade in prelimbic cortex of SHR masked the expected neutral effect of adolescent atomoxetine on adult cocaine self-administration behavior. Moreover, greater efficacy of acute idazoxan challenge in adult SHR after adolescent atomoxetine relative to vehicle is consistent with the idea that chronic atomoxetine may downregulate presynaptic α2A-adrenergic autoreceptors in SHR.en_US
dc.description.sponsorshipNational Institutes of Health grant DA011716. (DA011716 - National Institutes of Health)en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693724/
dc.format.extentp. 2897-2909en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherSpringeren_US
dc.relation.ispartofPsychopharmacology
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectPsychiatryen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectAtomoxetineen_US
dc.subjectAttention deficit/hyperactivity disorderen_US
dc.subjectCocaineen_US
dc.subjectIdazoxanen_US
dc.subjectNorepinephrineen_US
dc.subjectPrelimbic cortexen_US
dc.subjectSelf-administrationen_US
dc.subjectDeficit hyperactivity disorderen_US
dc.subjectImproves cognitive deficitsen_US
dc.subjectMedial prefrontal cortexen_US
dc.subjectD-amphetamine treatmenten_US
dc.subjectBiogenic-amine uptakeen_US
dc.subjectVentral bed nucleusen_US
dc.subjectWistar-Kyoto ratsen_US
dc.subjectMethylphenidate treatmenten_US
dc.subjectSeeking behavioren_US
dc.subjectAdrenergic uptake inhibitorsen_US
dc.subjectAdrenergic alpha-2 receptor antagonistsen_US
dc.subjectAge factorsen_US
dc.subjectAnimalsen_US
dc.subjectAtomoxetine hydrochlorideen_US
dc.subjectAttention deficit disorder with hyperactivityen_US
dc.subjectMaleen_US
dc.subjectMethylphenidateen_US
dc.subjectPrefrontal cortexen_US
dc.subjectRatsen_US
dc.subjectRats, Inbred SHRen_US
dc.subjectRats, inbred WKYen_US
dc.subjectSelf administrationen_US
dc.subjectSpecies specificityen_US
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.titleBlockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatmenten_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00213-017-4681-y
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-1866-9485 (Kantak, Kathleen M)
dc.description.oaversionPublished version


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International