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dc.contributor.authorJordan, Chloe J.
dc.contributor.authorLemay, Carley
dc.contributor.authorDwoskin, Linda P.
dc.contributor.authorKantak, Kathleen M.
dc.date.accessioned2019-02-08T19:29:21Z
dc.date.available2019-02-08T19:29:21Z
dc.date.issued2016-12-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387659500007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationChloe J Jordan, Carley Lemay, Linda P Dwoskin, Kathleen M Kantak. 2016. "Adolescent d-amphetamine treatment in a rodent model of attention deficit/hyperactivity disorder: impact on cocaine abuse vulnerability in adulthood." PSYCHOPHARMACOLOGY, Volume 233, Issue 23-24, pp. 3891 - 3903 (13). https://doi.org/10.1007/s00213-016-4419-2
dc.identifier.issn0033-3158
dc.identifier.issn1432-2072
dc.identifier.urihttps://hdl.handle.net/2144/33301
dc.description.abstractRATIONALE: Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse. Past research demonstrated that adolescent methylphenidate treatment increased several aspects of cocaine self-administration during adulthood using the spontaneously hypertensive rat (SHR) model of ADHD. Presently, we determined effects of the alternate stimulant medication, d-amphetamine, on cocaine self-administration. OBJECTIVES: We tested the hypothesis that adolescent d-amphetamine would not increase cocaine self-administration in adult SHR, given that d-amphetamine has a different mechanism of action than methylphenidate. METHODS: A pharmacologically relevant dose of d-amphetamine (0.5 mg/kg) or vehicle was administered throughout adolescence to SHR and two control strains, Wistar-Kyoto (WKY) and Wistar (WIS). Three aspects of cocaine abuse vulnerability were assessed in adulthood after discontinuing adolescent treatments: acquisition rate and dose-related responding under fixed (FR) and progressive (PR) ratio schedules. RESULTS: Adult SHR acquired cocaine self-administration faster and self-administered more cocaine across multiple doses compared to WKY and WIS under FR and PR schedules, indicating that SHR is a reliable animal model of comorbid ADHD and cocaine abuse. Relative to vehicle, SHR and WIS with adolescent d-amphetamine treatment self-administered less cocaine upon reaching acquisition criteria, and WIS additionally acquired cocaine self-administration more slowly and had downward shifts in FR and PR cocaine dose-response curves. WKY with adolescent d-amphetamine treatment acquired cocaine self-administration more quickly relative to vehicle. CONCLUSIONS: In contrast to methylphenidate, adolescent d-amphetamine did not augment cocaine self-administration in SHR. Adolescent d-amphetamine treatment actually protected against cocaine abuse vulnerability in adult SHR and WIS.en_US
dc.description.sponsorshipNational Institutes of Health grant DA011716 and the Clara Mayo Memorial Fellowship at Boston University. (DA011716 - National Institutes of Health; Clara Mayo Memorial Fellowship at Boston University)en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026317/en_US
dc.format.extentp. 3891-3903en_US
dc.languageEnglishen_US
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.relation.ispartofPsychopharmacologyen_US
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectPharmacology & Pharmacyen_US
dc.subjectPsychiatryen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectAdolescenceen_US
dc.subjectAttention deficit/hyperactivity disorderen_US
dc.subjectCocaine self-administrationen_US
dc.subjectd-Amphetamineen_US
dc.subjectSpontaneously hypertensive raten_US
dc.subjectAttention deficit disorder with hyperactivityen_US
dc.subjectCocaine-related disordersen_US
dc.subjectMaleen_US
dc.subjectRatsen_US
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.subjectPsychiatryen_US
dc.titleAdolescent d-amphetamine treatment in a rodent model of attention deficit/hyperactivity disorder: impact on cocaine abuse vulnerability in adulthooden_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00213-016-4419-2
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-1866-9485 (Kantak, Kathleen M)
dc.description.oaversionPublished versionen_US


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