Spatiotemporal techniques in multimodal imaging for brain mapping and epilepsy
Goldenholz, Daniel Mordechai
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This thesis explored multimodal brain imaging using advanced spatiotemporal techniques. The first set of experiments were based on simulations. Much controversy exists in the literature regarding the differences between magnetoencephalography (MEG) and electroencephalography (EEG}, both practically and theoretically. The differences were explored using simulations that evaluated the expected signal-to-noise ratios from reasonable brain sources. MEG and EEG were found to be complementary, with each modality optimally suited to image activity from different areas of the cortical surface. Consequently, evaluations of epileptic patients and general neuroscience experiments will both benefit from simultaneously collected MEG/EEG. The second set of experiments represent an example of MEG combined with magnetic resonance imaging (MRI) and functional MRI (fMRI) applied to healthy subjects. The study set out to resolve two questions relating to shape perception. First, does the brain activate functional areas sequentially during shape perception, as has been suggested in recent literature? Second, which , if any, functional areas are active time-locked with reaction-time? The study found that functional areas are non-sequentially activated, and that area IT is active time-locked with reaction-time. These two points, coupled with the method for multimodal integration , can help further develop our understanding of shape perception in particular, and cortical dynamics in general for healthy subjects. Broadly, these two studies represent practical guidelines for epilepsy evaluations and brain mapping studies. For epilepsy studies, clinicians could combine MEG and EEG to maximize the probability of finding the source of seizures. For brain mapping in general, EEG, MEG, MRI and fMRI can be combined in the methods outlined here to obtain more sophisticated views of cortical dynamics.
Thesis (Ph.D.)--Boston University
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