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dc.contributor.authorXie, Wentingen_US
dc.contributor.authorRoss, Erin E.en_US
dc.contributor.authorKramer, Mark A.en_US
dc.contributor.authorEden, Uri T.en_US
dc.contributor.authorChu, Catherine J.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2018-06-20
dc.date.accessioned2019-03-01T18:49:43Z
dc.date.available2019-03-01T18:49:43Z
dc.date.issued2018-09
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30187012
dc.identifier.citationWenting Xie, Erin E Ross, Mark A Kramer, Uri T Eden, Catherine J Chu. 2018. "Timing matters: Impact of anticonvulsant drug treatment and spikes on seizure risk in benign epilepsy with centrotemporal spikes.." Epilepsia Open, Volume 3, Issue 3, pp. 409 - 417. https://doi.org/10.1002/epi4.12248
dc.identifier.issn2470-9239
dc.identifier.urihttps://hdl.handle.net/2144/33695
dc.description.abstractOBJECTIVE: Benign epilepsy with centrotemporal spikes (BECTS) is a common, self-limited epilepsy syndrome affecting school-age children. Classic interictal epileptiform discharges (IEDs) confirm diagnosis, and BECTS is presumed to be pharmacoresponsive. As seizure risk decreases in time with this disease, we hypothesize that the impact of IEDs and anticonvulsive drug (ACD) treatment on the risk of subsequent seizure will differ based on disease duration. METHODS: We calculate subsequent seizure risk following diagnosis in a large retrospective cohort of children with BECTS (n = 130), evaluating the impact of IEDs and ACD treatment in the first, second, third, and fourth years of disease. We use a Kaplan-Meier survival analysis and logistic regression models. Patients were censored if they were lost to follow-up or if they changed group status. RESULTS: Two-thirds of children had a subsequent seizure within 2 years of diagnosis. The majority of children had a subsequent seizure within 3 years despite treatment. The presence of IEDs on electroencephalography (EEG) did not impact subsequent seizure risk early in the disease. By the fourth year of disease, all children without IEDs remained seizure free, whereas one-third of children with IEDs at this stage had a subsequent seizure. Conversely, ACD treatment corresponded with lower risk of seizure early in the disease but did not impact seizure risk in later years. SIGNIFICANCE: In this cohort, the majority of children with BECTS had a subsequent seizure despite treatment. In addition, ACD treatment and IEDs predicted seizure risk at specific points of disease duration. Future prospective studies are needed to validate these exploratory findings.en_US
dc.format.extentp. 409 - 417en_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofEpilepsia Open
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBenign epilepsy with centrotemporal spikesen_US
dc.subjectBiomarkeren_US
dc.subjectInterictal epileptiform dischargesen_US
dc.subjectSeizure risken_US
dc.subjectTreatmenten_US
dc.titleTiming matters: impact of anticonvulsant drug treatment and spikes on seizure risk in benign epilepsy with centrotemporal spikesen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1002/epi4.12248
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Mathematics & Statisticsen_US
pubs.publication-statusPublished onlineen_US


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