Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • Centers & Institutes
    • Pulmonary Center
    • Pulmonary Center Papers
    • View Item
    •   OpenBU
    • Centers & Institutes
    • Pulmonary Center
    • Pulmonary Center Papers
    • View Item

    Orally Available Mn Porphyrins with Superoxide Dismutase and Catalase Activities

    Thumbnail
    Date Issued
    2009-6-6
    Publisher Version
    10.1007/s00775-009-0550-4
    Author(s)
    Rosenthal, Rosalind A.
    Huffman, Karl D.
    Fisette, Leslie W.
    Damphousse, Christy A.
    Callaway, Wyeth B.
    Malfroy, Bernard
    Doctrow, Susan R.
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Permanent Link
    https://hdl.handle.net/2144/3391
    Citation (published version)
    Rosenthal, Rosalind A., Karl D. Huffman, Leslie W. Fisette, Christy A. Damphousse, Wyeth B. Callaway, Bernard Malfroy, Susan R. Doctrow. "Orally available Mn porphyrins with superoxide dismutase and catalase activities" Journal of Biological Inorganic Chemistry 14(6): 979-991. (2009)
    Abstract
    Superoxide dismutase/catalase mimetics, such as salen Mn complexes and certain metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have been implicated in the pathogenesis of many serious diseases. Both classes of mimetic are protective in animal models of oxidative stress. However, only AEOL11207 and EUK-418, two uncharged Mn porphyrins, have been shown to be orally bioavailable. In this study, EUK-418 and several new analogs (the EUK-400 series) were synthesized and shown to exhibit superoxide dismutase, catalase, and peroxidase activities in vitro. Some also protected PC12 cells against staurosporine-induced cell death. All EUK-400 compounds were stable in simulated gastric fluid, and most were substantially more lipophilic than the salen Mn complexes EUK-189 and EUK-207, which lack oral activity. Pharmacokinetics studies demonstrate the presence of all EUK-400 series compounds in the plasma of rats after oral administration. These EUK-400 series compounds are potential oral therapeutic agents for cellular damage caused by oxidative stress. ELECTRONIC SUPPLEMENTARY MATERIAL. The online version of this article (doi:10.1007/s00775-009-0550-4) contains supplementary material, which is available to authorized users.
    Rights
    Copyright The Author(s) 2009
    Collections
    • Pulmonary Center Papers [21]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help