Show simple item record

dc.contributor.authorEinhorn, Thomas A.en_US
dc.date.accessioned2012-01-12T17:39:15Z
dc.date.available2012-01-12T17:39:15Z
dc.date.issued2002-10-21
dc.identifier.citationEinhorn, Thomas A. "Cox-2: Where are we in 2003? - The role of cyclooxygenase-2 in bone repair" Arthritis Research & Therapy 5(1): 5-7. (2002)
dc.identifier.issn1478-6362
dc.identifier.urihttps://hdl.handle.net/2144/3416
dc.description.abstractProstaglandins are important mediators of bone repair, and cyclooxygenases are required for prostaglandin production. Data from animal studies suggest that both non-specific and specific inhibitors of cyclooxygenases impair fracture healing but that this is due to the inhibition of COX-2 and not COX-1. Although these data raise concerns about the use of COX-2-specific inhibitors as anti-inflammatory or anti-analgesic drugs in patients undergoing bone repair, clinical reports have been inconclusive. Because animal data suggest that the effects of COX-2 inhibitors are both dose-dependent and reversible, in the absence of scientifically sound clinical evidence it is suggested that physicians consider short-term administration or other drugs in the management of these patients.en_US
dc.language.isoen
dc.publisherBioMed Centralen_US
dc.subjectBone repairen_US
dc.subjectCyclooxygenase-2en_US
dc.subjectFracture healingen_US
dc.subjectNon-steroidal anti-inflammatory drugsen_US
dc.subjectProstaglandinsen_US
dc.titleCox-2: Where Are We in 2003? - The Role of Cyclooxygenase-2 in Bone Repairen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/ar607
dc.identifier.pmid12716441
dc.identifier.pmcid154427


This item appears in the following Collection(s)

Show simple item record