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    Relation of subjective quality of life to motor symptom profile in Parkinson's disease

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    Attribution 4.0 International
    Date Issued
    2011
    Publisher Version
    10.4061/2011/472830
    Author(s)
    Appleman, E. R.
    Stavitsky, K.
    Cronin-Golomb, Alice
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    Permanent Link
    https://hdl.handle.net/2144/34367
    Version
    Published version
    Citation (published version)
    ER Appleman, K Stavitsky, A Cronin-Golomb. 2011. "Relation of subjective quality of life to motor symptom profile in Parkinson's disease." Parkinson’s Disease, Volume 2011, https://doi.org/10.4061/2011/472830
    Abstract
    Parkinson's disease (PD) presents with extensive heterogeneity in symptomatology, inviting examination of disease subtypes. One significant categorization is by whether patients present at onset with tremor as the dominant symptom (TD) or with nontremor symptoms (NTD). We examined differences in quality of life between TD and NTD patients using the Parkinson's Disease Questionnaire-39 (PDQ-39), correlating performance with aspects of motor function as indexed by the Unified Parkinson's Disease Rating Scale (UPDRS). Participants included 35 nondemented individuals (19 TD, 16 NTD) matched on clinical and demographic characteristics. NTD had significantly lower overall PDQ-39 scores, particularly for the mobility subscale. Several UPDRS subscale scores significantly correlated with quality of life, especially for NTD. Further, the correlations were driven by nontremor type symptoms, even in TD patients. Determining reliable subtypes of PD may aid in prognosis and treatment optimization, thereby enhancing quality of life in afflicted individuals.
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    Attribution 4.0 International
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    • CAS: Psychological and Brain Sciences: Scholarly Papers [232]
    • BU Open Access Articles [3727]


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