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dc.contributor.authorLin, Cheng-Chiehen_US
dc.contributor.authorWagenaar, Robert C.en_US
dc.contributor.authorYoung, Danielen_US
dc.contributor.authorSaltzman, Elliot L.en_US
dc.contributor.authorRen, Xiaolinen_US
dc.contributor.authorNeargarder, Sandyen_US
dc.contributor.authorCronin-Golomb, Aliceen_US
dc.date.accessioned2019-04-03T13:15:25Z
dc.date.available2019-04-03T13:15:25Z
dc.date.issued2014
dc.identifier.citationC Lin, RC Wagenaar, D Young, EL Saltzman, X Ren, S Neargarder, A Cronin-Golomb. 2014. "Effects of Parkinson’s disease on optic flow perception for heading direction during navigation." Experimental brain research, Volume 232, Issue 4, pp. 1343 - 1355. https://doi.org/10.1007/s00221-014-3853-9
dc.identifier.issn0014-4819
dc.identifier.urihttps://hdl.handle.net/2144/34397
dc.description.abstractVisuoperceptual disorders have been identified in individuals with Parkinson’s disease (PD) and may affect the perception of optic flow for heading direction during navigation. Studies in healthy subjects have confirmed that heading direction can be determined by equalizing the optic flow speed (OS) between visual fields. The present study investigated the effects of PD on the use of optic flow for heading direction, walking parameters, and interlimb coordination during navigation, examining the contributions of OS and spatial frequency (dot density). Twelve individuals with PD without dementia, 18 age-matched normal control adults (NC), and 23 young control adults (YC) walked through a virtual hallway at about 0.8 m/s. The hallway was created by random dots on side walls. Three levels of OS (0.8, 1.2, and 1.8 m/s) and dot density (1, 2, and 3 dots/m2) were presented on one wall while on the other wall, OS and dot density were fixed at 0.8 m/s and 3 dots/m2, respectively. Three-dimensional kinematic data were collected, and lateral drift, walking speed, stride frequency and length, and frequency, and phase relations between arms and legs were calculated. A significant linear effect was observed on lateral drift to the wall with lower OS for YC and NC, but not for PD. Compared to YC and NC, PD veered more to the left under OS and dot density conditions. The results suggest that healthy adults perceive optic flow for heading direction. Heading direction in PD may be more affected by the asymmetry of dopamine levels between the hemispheres and by motor lateralization as indexed by handedness.en_US
dc.format.extentp. 1343 - 1355en_US
dc.language.isoen_US
dc.publisherSpringer Berlin Heidelbergen_US
dc.relation.ispartofExperimental brain research
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectParkinson's diseaseen_US
dc.subjectVisual perceptionen_US
dc.subjectOptic flowen_US
dc.subjectNavigationen_US
dc.subjectLocomotionen_US
dc.subjectLeft hemiparkinsons-diseaseen_US
dc.subjectVisual evoked-potentialsen_US
dc.subjectStride length regulationen_US
dc.subjectAble-bodied gaiten_US
dc.subjectVelocity discriminationen_US
dc.subjectSpatial-frequencyen_US
dc.subjectVirtual-realityen_US
dc.subjectLine bisectionen_US
dc.subjectLeg movementsen_US
dc.subjectHuman walkingen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectOrientationen_US
dc.subjectPhotic stimulationen_US
dc.subjectPsychomotor performanceen_US
dc.subjectVirtual reality exposure therapyen_US
dc.subjectYoung adulten_US
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.subjectNeurology & neurosurgeryen_US
dc.titleEffects of Parkinson’s disease on optic flow perception for heading direction during navigationen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1007/s00221-014-3853-9
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Physical Therapy and Athletic Trainingen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0001-5699-6204 (Cronin-Golomb, A)
dc.identifier.mycv38528
dc.identifier.mycv38528


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