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dc.contributor.authorBaum, Karina J.en_US
dc.contributor.authorRen, Ruibaoen_US
dc.date.accessioned2012-01-12T17:49:13Z
dc.date.available2012-01-12T17:49:13Z
dc.date.copyright2008
dc.date.issued2008-6-5
dc.identifier.citationBaum, Karina J., Ruibao Ren. "Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis" Journal of Hematology and Oncology 1:5. (2008)
dc.identifier.issn1756-8722
dc.identifier.urihttps://hdl.handle.net/2144/3450
dc.description.abstractRas small GTPases are activated in many hematopoietic growth factor signaling and in hematological malignancies, but their role in hematopoiesis and leukemogenesis is not completely known. Here we examined the effect of Ras inhibition by a dominant negative mutant of Ras, N17 H-Ras, in adult hematopoiesis and in BCR/ABL leukemogenesis using the mouse bone marrow transduction and transplantation approach. We found that N17 H-Ras expression suppressed B- and T-lymphopoiesis and erythropoiesis. Interestingly, N17 H-Ras did not suppress myelopoiesis in the bone marrow, yet it greatly attenuated BCR/ABL-induced chronic myelogenous leukemia (CML)-like myeloproliferative disease. Most BCR/ABL + N17 H-Ras mice eventually developed pro-B lymphoblastic leukemia/lymphoma (B-ALL). These results suggest that Ras activation is essential for the development of lymphoid and erythroid cells but not myeloid cells and that Ras is a critical target of BCR/ABL in the pathogenesis of CML, but not B-ALL.en_US
dc.description.sponsorshipNational Cancer Institute grant (CA68008)en_US
dc.language.isoen
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2008 Baum and Ren; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleEffect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesisen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1756-8722-1-5
dc.identifier.pmid18577264
dc.identifier.pmcid2438443


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Copyright 2008 Baum and Ren; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2008 Baum and Ren; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.