Autoradiographic investigation of utilization of leucine-H3 in the ventral and dorsal cochlear nuclei
Das, Gopal Dwarka
MetadataShow full item record
Alterations in protein metabolism (determined by the utilization of DL-Leucine-4,5-H3HCl) were studied autoradiographically in the ventral and dorsal cochlear nuclei of rats, following partial destruction of the cochlea and intense acoustic stimulation. The auditory stimulation of 600 cps at 99-103 db was presented chronically (one hour a day for six weeks) and acutely (two hours only). Each animal was injected intraperitoneally 1.87 mc of radioleucine in two doses (1.00 mc and 0.87 mc) with an interval of 30 minutes. After the second injection 30 minutes were allowed, thus permitting a total of 60 minutes for exchange of the radiochemical. Animals from the surgical, chronic stimulation and control groups rested during the exchange period, whereas animals from the acute stimulation group were subjected to the intense auditory stimulation [TRUNCATED]
Thesis (Ph.D.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at email@example.com. Thank you.