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    Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics

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    Copyright 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
    Date Issued
    2009-7-20
    Publisher Version
    10.3390/ijerph6072007
    Author(s)
    Fortier, Catherine Brawn
    Maksimovskiy, Arkadiy L.
    Venne, Jonathan R.
    LaFleche, Ginette
    McGlinchey, Regina E.
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    Permanent Link
    https://hdl.handle.net/2144/3453
    Citation (published version)
    Fortier, Catherine Brawn, Arkadiy L. Maksimovskiy, Jonathan R. Venne, Ginette LaFleche, Regina E. McGlinchey. "Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics" International Journal of Environmental Research and Public Health 6(7): 2007-2027. (2009)
    Abstract
    Chronic alcoholism has profound effects on the brain, including volume reductions in regions critical for eyeblink classical conditioning (EBCC). The current study challenged abstinent alcoholics using delay (n = 20) and trace (n = 17) discrimination/reversal EBCC. Comparisons revealed a significant difference between delay and trace conditioning performance during reversal (t (35) = 2.08, p < 0.05). The difference between the two tasks for discrimination was not significant (p = 0.44). These data support the notion that alcoholics are increasingly impaired in the complex task of reversing a previously learned discrimination when a silent trace interval is introduced. Alcoholics' impairment in flexibly altering learned associations may be central to their continued addiction.
    Rights
    Copyright 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
    Collections
    • Memory Disorders Research Center Papers [2]


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