Inhibition of enzymes of the arginine and pyrimidine biosynthetic pathways by pyrimidine metabolites
Lou, Marjorie Jan-Yung Feng
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In Neurospora, as in other organisms, arginine and pyrimidine biosynthesis shares the common precursor, carbamyl phosphate. The fact that some mutants require only pyrimidines for growth while others require only arginine for growth indicates the possibility of two independent modes for carbamyl phosphate synthesis and utilization. The existence of two carbamyl phosphokinases has been hypothesized to resolve the interplay of nutritional requirements for arginine and pyrimidine. One carbamyl phosphokinase catalyzes the formation of carbamyl phosphate specific for the arginine pathway and the other carbamyl phosphokinase catalyzes the formation of carbamyl phosphate specific for the pyrimidine pathway [TRUNCATED]
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