Show simple item record

dc.contributor.authorGenderson, M. R.en_US
dc.contributor.authorRana, B. K.en_US
dc.contributor.authorPanizzon, M. S.en_US
dc.contributor.authorGrant, M. D.en_US
dc.contributor.authorToomey, Rosemaryen_US
dc.contributor.authorJacobson, K. C.en_US
dc.contributor.authorXian, H.en_US
dc.contributor.authorCronin‐Golomb, Aliceen_US
dc.contributor.authorFranz, C. E.en_US
dc.contributor.authorKremen, W. S.en_US
dc.date.accessioned2019-04-29T14:03:54Z
dc.date.available2019-04-29T14:03:54Z
dc.date.issued2013
dc.identifier.citationMR Genderson, BK Rana, MS Panizzon, MD Grant, R Toomey, KC Jacobson, H Xian, A Cronin‐Golomb, CE Franz, WS Kremen. 2013. "Genetic and environmental influences on sleep quality in middle‐aged men: a twin study." Journal of sleep research, Volume 22, Issue 5, pp. 519 - 526.
dc.identifier.issn1365-2869
dc.identifier.urihttps://hdl.handle.net/2144/34943
dc.description.abstractPoor sleep quality is a risk factor for a number of cognitive and physiological age-related disorders. Identifying factors underlying sleep quality are important in understanding the etiology of these age-related health disorders. We investigated the extent to which genes and the environment contribute to subjective sleep quality in middle-aged male twins using the classical twin design. We used the Pittsburgh Sleep Quality Index to measure sleep quality in 1218 middle-aged twin men from the Vietnam Era Twin Study of Aging (mean age = 55.4 years; range 51-60; 339 monozygotic twin pairs, 257 dizygotic twin pairs, 26 unpaired twins). The mean PSQI global score was 5.6 [SD = 3.6; range 0-20]. Based on univariate twin models, 34% of variability in the global PSQI score was due to additive genetic effects (heritability) and 66% was attributed to individual-specific environmental factors. Common environment did not contribute to the variability. Similarly, the heritability of poor sleep-a dichotomous measure based on the cut-off of global PSQI>5-was 31%, with no contribution of the common environment. Heritability of six of the seven PSQI component scores (subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, and daytime dysfunction) ranged from 0.15 to 0.31, whereas no genetic influences contributed to the use of sleeping medication. Additive genetic influences contribute to approximately one-third of the variability of global subjective sleep quality. Our results in middle-aged men constitute a first step towards examination of the genetic relationship between sleep and other facets of aging.en_US
dc.format.extentp. 519 - 526en_US
dc.language.isoen_US
dc.relation.ispartofJournal of sleep research
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectClinical neurologyen_US
dc.subjectNeurosciencesen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectHeritabilityen_US
dc.subjectPSQIen_US
dc.subjectSleep qualityen_US
dc.subjectTwinsen_US
dc.subjectVETSAen_US
dc.subjectVietnam era twinen_US
dc.subjectPopulation-based twinen_US
dc.subjectHealthy-individualsen_US
dc.subjectInfant sleepen_US
dc.subjectDurationen_US
dc.subjectAdultsen_US
dc.subjectIndexen_US
dc.subjectInsomniaen_US
dc.subjectHypertensionen_US
dc.subjectDifficultiesen_US
dc.subjectAgingen_US
dc.subjectEnvironmenten_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectSleepen_US
dc.subjectSleep wake disordersen_US
dc.subjectTime factorsen_US
dc.subjectTwins, dizygoticen_US
dc.subjectTwins, monozygoticen_US
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.titleGenetic and environmental influences on sleep quality in middle‐aged men: a twin studyen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doihttps://doi.org/10.1111/jsr.12048
pubs.elements-sourcemanual-entryen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US


This item appears in the following Collection(s)

Show simple item record