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dc.contributor.authorBrock, George Matthewen_US
dc.date.accessioned2019-05-16T13:26:54Z
dc.date.available2019-05-16T13:26:54Z
dc.date.issued2002
dc.date.submitted2002
dc.identifier.other(OCoLC)50923920
dc.identifier.otherb24504294
dc.identifier.urihttps://hdl.handle.net/2144/35605
dc.descriptionThesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2002 (Endodontics).en_US
dc.descriptionIncludes bibliographical references (leaves 56-75).en_US
dc.description.abstractDiabetic individuals are more susceptible to infection than normal individuals. Infections of diabetics tend to be more severe and are more likely to have serious systemic complications. Porphyromonas gingivalis , an anaerobic Gram-negative bacterium, is associated with adult periodontitis and lesions of endodontic origin. Infections by P. gingivalis result in necrosis of soft tissues and the activation of inflammatory responses that lead to induction of osteoclastogenesis. Polymorphonuclear cells (PMNs), components of the innate immune response, act as the primary leukocyte that counteracts bacterial infection. The objective of this study was to test the hypothesis that diabetes alters the inflammatory response to P. gingivalis. The host response to P. gingivalis in diabetic and matched control mice following injection with live P. gingivalis or P. gingivalis lipopolysaccharide (LPS) into the scalp was evaluated and the recruitment of PMNs and the necrosis of P. gingivalis infected tissue was assessed. Mice were sacrificed 1 day and 3 days after injection. On day 1, P. gingivalis induced areas of necrosis that were similar in normal and diabetic mice (p>0.05 , Student 's T test). On day 3, there were 3.35 PMN/field in the diabetic mice, which was 55% greater than control mice, (2.17 PMN/field) , and was statistically significant (p<0.05). Similar results were obtained with P. gingivalis LPS. These results indicate that the initial responses to P. gingivalis are similar in normal and diabetic mice, but that there are prolonged inflammatory responses in diabetic mice.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.en_US
dc.subjectDiabetes mellitusen_US
dc.subjectPorphyromonas gingivalisen_US
dc.titleIncreased inflammation in response to Porphyromonas gingivalis in diabetic miceen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Science in Dentistryen_US
etd.degree.levelmastersen_US
etd.degree.disciplineEndodonticsen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.mmsid


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