Show simple item record

dc.contributor.authorDabbagh, Walid K.en_US
dc.date.accessioned2019-05-16T13:27:06Z
dc.date.available2019-05-16T13:27:06Z
dc.date.issued1996
dc.date.submitted1996
dc.identifier.other(OCoLC)41341123
dc.identifier.otherb22385903
dc.identifier.urihttps://hdl.handle.net/2144/35608
dc.descriptionIncludes bibliography: (leaves 114-124).en_US
dc.descriptionThesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 1996 (Oral Biology).en_US
dc.description.abstractHistatins are a group of histidine-rich antimicrobial proteins present in human salivary secretions. Previous studies have shown that histatins play an important role in the maintenance of enamel integrity and defense against oral bacteria and fungal pathogens in the oral cavity. Because histatins differ in their ability to inhibit blastopore viability and germ tube formation, it is important to be able to quantitatively determine individual histatin concentrations. Such determinations would be essential for understanding and comparing the antibacterial activities of the saliva in healthy and diseased persons, and in finding a relation between individual histatin concentration and function. The present study is focused on determination of the physiological concentration of the major histatins 1, 3, and 5 in glandular secretions and whole saliva in order to evaluate the relationship of individual histatin concentrations to their functional capacity in the oral cavity. Human parotid and submandibular / sublingual secretions were collected from 19 healthy donors in the presence and absence of gustatocy stimulation. Whole saliva was collected from the same group of donors with masticatocy stimulation. A cationic polyaccylamide gel electrophoresis system (cationic PAGE) was used in combination with scanning densitometcy to measure the [TRUNCATED].en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.en_US
dc.subjectOral biologyen_US
dc.subjectSalivary proteins and peptidesen_US
dc.titlePhysiological concentration of human salivary histatins in glandular secretions and whole salivaen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameDoctor of Science in Dentistryen_US
etd.degree.leveldoctoralen_US
etd.degree.disciplineOral Biologyen_US
etd.degree.grantorBoston Universityen_US


This item appears in the following Collection(s)

Show simple item record