Show simple item record

dc.contributor.authorFu, Earl Hahnen_US
dc.date.accessioned2019-05-16T13:27:11Z
dc.date.available2019-05-16T13:27:11Z
dc.date.issued1982
dc.date.submitted1982
dc.identifier.other9473373
dc.identifier.otherb14401666
dc.identifier.urihttps://hdl.handle.net/2144/35609
dc.descriptionThesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1982 (Oral biology)en_US
dc.descriptionBibliography: leaves 102-114.en_US
dc.description.abstractThe eyes, the trigeminal ganglia and the superior cervical ganglia of CD-1 mice were studied as a model for recurrent herpetic infections. Animals were corneally infected with Type 1 herpes simplex virus (HSV-1). During the period of acute infection, both gnaglionic tissues were demonstrated to have almost 100% infection with herpes virus. Following recovery from the acute infection, HSV was shown to be latent in both ganglionic tissues; the HSV could be demonstrated in over 75% of trigeminal ganglia and approximately 20% of superior cervical ganglia by explantation of gnaglia. During t he latent phase, spontaneous reactivation in both ocular and ganglionic t issues were uncommon in our animals. Different stimuli, including fever, thermal burn, mechanical trauma, treatment with cyclophosphamide (CPA), an immunosuppressant, and physical stress were employed in attempts to induce recurrent infection. Daily cultures of eye swabbings and cultures of homogenates of the ganglia were used to sutdy effects of these stimuli on virus reactivation. A low incidence of reactivation (approximately 10%) was demonstrated in eyes and trigeminal gnaglia following CPA trea t men~ of these mice. The other stimuli apparently p~oduced no reactivation of infection in our animals. This mouse eye model may still prove to be useful for studying the mechaniams of viral latency and reactivation in herpetic infection, and thus warrants investigation.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.en_US
dc.subjectHerpes simplexen_US
dc.titleEvaluation of the mouse eye as a model for recurrent herpetic infectionen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameDoctor of Science in Dentistryen_US
etd.degree.leveldoctoralen_US
etd.degree.disciplineOral Biologyen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.mmsid


This item appears in the following Collection(s)

Show simple item record