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dc.contributor.authorGillen, Thomasen_US
dc.date.accessioned2019-05-16T13:27:19Z
dc.date.available2019-05-16T13:27:19Z
dc.date.issued2002
dc.date.submitted2002
dc.identifier.other(OCoLC)50923834
dc.identifier.otherb24504257
dc.identifier.urihttps://hdl.handle.net/2144/35611
dc.descriptionThesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2002 (Endodontics).en_US
dc.descriptionIncludes bibliography (leaves 63-68).en_US
dc.description.abstractThe role of inflammatory mediators in surgical repair has not been delineated. Tumor necrosis factor alpha (TNFa) and interleukin-1 beta (IL-1~) are cytokines, which are recognized as potent stimulators of the initial inflammatory response. In our study we tested the hypothesis that stimulation by the inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) are necessary for osseous and soft tissue wound healing. A calvarial osteotomy, 1mm in diameter, was created in three groups of mice: one with targeted deletions of the TNF receptors p55 and p75, one with targeted deletions of the IL-1 receptor type I, and one with wild-type (control) mice. Bone healing was assessed by quantitative histomorphometry. Because three mice died, the number of animals in the experiment was not large enough to produce viable statistical results. However, we observed reduced osseous healing between the experimental groups (TNF p55- /p75- and IL-1 -/-) and the control group at Day 14. [TRUNCATED]en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.en_US
dc.subjectBone regenerationen_US
dc.subjectInterleukin 1en_US
dc.subjectEndodonticsen_US
dc.subjectTumor necrosis factoren_US
dc.subjectWound healingen_US
dc.titleThe effects of tumor necrosis factor and interleukin 1 on osseous and soft tissue wound healingen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Science in Dentistryen_US
etd.degree.levelmastersen_US
etd.degree.disciplineEndodonticsen_US
etd.degree.grantorBoston Universityen_US


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