The role of advanced glycosylated end products in the stimulation of signaling pathways in fibroblast apoptosis and the proposed association with the formation of type II diabetes mellitus complications
Melito, Christine Marie MacLellan
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BACKGROUND Advanced glycosylation end products (AGEs) have been implicated in multi-organ diabetic complications including artherosclerosis, nephropathy, neuropathy, retinopathy, and decreased wound healing. AG Es aggregate as a result of increased glycation modifications, which occur during chronic hyperglycemic states such as diabetes. Accumulation of these by-products consequently allows for the formation of free radicals, which is believed to contribute to apoptotic events that lead to tissue destruction and thus systemic complications seen in diabetic patients. The goal of this study was to investigate signaling pathways by which AGE induced fibroblast apoptosis occurs and the proposed association with type II diabetes mellitus wound healing complications. [TRUNCATED]
Thesis (MSD)--Boston University, Goldman School of Dental Medicine, 2007 (Endodontics).Includes bibliographical references: leaves 77-92.
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