Regenerative potentials of decalcified bone matrix
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Decalcified allogenic bone matrices were implanted in var1ous areas such as fracture sites, joint spaces, bony , defects, intact cortical bones and on edentulous ridges in rats, dogs and monkeys. Clinical, radiographic, fluorscent and histo-logical studies revealed that such grafts were resorbed and replaced by new bone. Decalcified allogenic bone grafts have great potential in new bone formation and they are not rejected from the implanted sites. Calcium determination of fibular fracture gaps in rats treated with decalcified allogenic bone matrix (DABM) , decalcified xenogenic bone matrix (DXBM), fresh autologous bone grafts (FAuBG's) and fresh allogenic bone grafts (FAlBG's) revealed that there was a gradual increase in calcium contents at sites treated with DABM and a return to near normal limits in eight weeks. Fracture gaps treated with DXBM showed a very slow increase in Ca after four weeks, thus a very slow and gradual calcification. There was a decrease in Ca contents in gaps treated with FAuBG's and FAlBG's for first two weeks and then followed by a gradual increase in Ca contents. Most of DXBM grafts and FAlBG's were exfoliated from the tissues,whereas all DABM grafts and FAuBG's were accepted by the host tissues. Fibular fractures treated with DABM demonstrated early healing, bony union and prevented fibrous union, where as in the control animals fracture gaps treated without DABM showed nonunion and fibrous tissue presence. Similar results of new ... [TRUNCATED]
Thesis (D.Sc.D.)--Boston University School of Graduate Dentistry.Bibliography included.
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