Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • Goldman School of Dental Medicine
    • GSDM: Historical Theses and Dissertations (Open Access)
    • View Item
    •   OpenBU
    • Goldman School of Dental Medicine
    • GSDM: Historical Theses and Dissertations (Open Access)
    • View Item

    Altered lymphocyte activation and macrophage apoptosis in diabetic mice

    Thumbnail
    Date Issued
    2004
    Author(s)
    Popek, Barbara Irene
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Permanent Link
    https://hdl.handle.net/2144/35629
    Abstract
    The purpose of this study was to explore whether lymphocyte activation and mononuclear cell apoptosis is dis-regulated by a diabetic situation which results in altered responses to bacterial infection. Based on other investigator's results NO production by macrophages is increased in diabetic mice therefore, the effects of NO on these processes are also examined. Diabetic (db-/db-) and background matched control (db+/db-) mice were injected with or without LPS. An iNOS inhibitor (AMT) was used in selected experiments. Activation of spleen lymphocytes and apoptosis of the mononuclear cells was examined using flow cytometry and ELISA. The results suggest that diabetes could affect lymphocyte activation and macrophage apoptosis. Nitric oxide may play a role in CD69 expression by diabetic T lymphocytes and have an opposite effect on B lymphocytes. These findings support the hypothesis that the kinetics and magnitude of the host response in diabetic and normal mice are different, which leads to an altered inflammatory course during the microbial infection.
    Description
    Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004 (Periodontology).
     
    Includes bibliography (leaves 41-50).
     
    Rights
    This work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.
    Collections
    • GSDM: Historical Theses and Dissertations (Open Access) [177]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help