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dc.contributor.authorPopek, Barbara Ireneen_US
dc.date.accessioned2019-05-16T13:34:06Z
dc.date.available2019-05-16T13:34:06Z
dc.date.issued2004
dc.date.submitted2004
dc.identifier.other(OCoLC)57032132
dc.identifier.otherb25311025
dc.identifier.urihttps://hdl.handle.net/2144/35629
dc.descriptionThesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004 (Periodontology).en_US
dc.descriptionIncludes bibliography (leaves 41-50).en_US
dc.description.abstractThe purpose of this study was to explore whether lymphocyte activation and mononuclear cell apoptosis is dis-regulated by a diabetic situation which results in altered responses to bacterial infection. Based on other investigator's results NO production by macrophages is increased in diabetic mice therefore, the effects of NO on these processes are also examined. Diabetic (db-/db-) and background matched control (db+/db-) mice were injected with or without LPS. An iNOS inhibitor (AMT) was used in selected experiments. Activation of spleen lymphocytes and apoptosis of the mononuclear cells was examined using flow cytometry and ELISA. The results suggest that diabetes could affect lymphocyte activation and macrophage apoptosis. Nitric oxide may play a role in CD69 expression by diabetic T lymphocytes and have an opposite effect on B lymphocytes. These findings support the hypothesis that the kinetics and magnitude of the host response in diabetic and normal mice are different, which leads to an altered inflammatory course during the microbial infection.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.en_US
dc.subjectApoptosisen_US
dc.subjectDiabetes millitusen_US
dc.subjectMacrophagesen_US
dc.titleAltered lymphocyte activation and macrophage apoptosis in diabetic miceen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Science in Dentistryen_US
etd.degree.levelmastersen_US
etd.degree.disciplinePeriodontologyen_US
etd.degree.grantorBoston Universityen_US


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