Identifications of gluten-degrading bacteria in human fecal samples
Valery Lara, Adriana Carolina
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Celiac Disease (CD) is a chronic inflammatory and autoimmune disorder of the small intestine characterized by an aberrant immune response to gluten proteins (primarily gliadins). Gluten are found in wheat, barley and rye and cause CD in genetically predisposed individuals. The genetic predisposition is given by the presence of either HLA-DQ2 or HLA-DQ8 genes in CD patients. Autoantibodies to tissue transglutaminase (TG2) and gluten are present as a consequence of the activation of the adaptive immune system. CD presents clinically with diarrhea and intestinal discomfort due to villous atrophy and may lead to anemia, osteoporosis and lymphomas. All signs and symptoms of celiac disease are triggered by the ingestion of gluten. Thus, the treatment of CD consists of strict exclusion of gluten from the diet, being the only treatment option currently available. The diet is very difficult to comply with, and gluten contamination in foods is a major problem for the CD patient ... [TRUNCATED]
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2013 (Department of Molecular and Cell Biology).Includes bibliography: leaves 52-59.
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